Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation

Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiationResting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation

Little is understood about how cells regulate and combine distinct biosynthetic pathways governing differentiation and cell division. For B-lineage cells it’s broadly accepted that activated cells should full a number

Immunohistochemical evaluation of spinal twine lesions in amyotrophic lateral sclerosis utilizing microtubule-associated protein 2 (MAP2) antibodies.

Immunohistochemical analysis of spinal cord lesions in amyotrophic lateral sclerosis using microtubule-associated protein 2 (MAP2) antibodies.Immunohistochemical analysis of spinal cord lesions in amyotrophic lateral sclerosis using microtubule-associated protein 2 (MAP2) antibodies.

We have now studied microtubule-associated protein 2 (MAP2) expression in anterior horn neurons within the cervical and lumbar spinal cords of 19 instances of adult-onset sporadic amyotrophic lateral sclerosis (ALS)

Mathematical Models of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Transferrin Receptor and the Insulin Receptor

Mathematical Models of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Transferrin Receptor and the Insulin ReceptorMathematical Models of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Transferrin Receptor and the Insulin Receptor

We develop and analyze mathematical fashions for receptor-mediated transcytosis of monoclonal antibodies (MAb) focusing on the transferrin receptor (TfR) or the insulin receptor (IR), that are expressed on the blood-brain

Development of a Hyaluronic Acid-Based Nanocarrier Incorporating Doxorubicin and Cisplatin as a pH-Sensitive and CD44-Targeted Anti-Breast Cancer Drug Delivery System

Development of a Hyaluronic Acid-Based Nanocarrier Incorporating Doxorubicin and Cisplatin as a pH-Sensitive and CD44-Targeted Anti-Breast Cancer Drug Delivery SystemDevelopment of a Hyaluronic Acid-Based Nanocarrier Incorporating Doxorubicin and Cisplatin as a pH-Sensitive and CD44-Targeted Anti-Breast Cancer Drug Delivery System

Tumor-targeting nanomaterial-based chemotherapeutic drug supply programs have been proven to symbolize an efficacious method for the therapy of most cancers due to their stability in blood circulation and predictable supply

Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro

Targeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitroTargeting shear gradient activated von Willebrand factor by the novel single-chain antibody A1 reduces occlusive thrombus formation in vitro

Intraluminal thrombus formation precipitates circumstances corresponding to acute myocardial infarction and disturbs native blood movement leading to areas of quickly altering blood movement velocities and steep gradients of blood shear

Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies

Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 AntibodiesInhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies

The household of PIM serine/threonine kinases consists of three extremely conserved oncogenes, PIM1, PIM2, and PIM3, which regulate a number of pro-survival pathways and cooperate with different oncogenes comparable to